Life Sciences

New life sciences research from N. Rocques and colleagues discussed

Published in Cancer Weekly, January 15th, 2008

New investigation results, 'GSK-3-mediated phosphorylation enhances Maf-transforming activity,' are detailed in a study published in Molecular Cell. "The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes," scientists in Orsay, France report.

"Maf proteins are overexpressed in about 50% of human multiple myelomas. Here, we show that Maf-transforming activity is controlled by GSK-3-dependent phosphorylation and that phosphorylation by GSK-3 can increase the oncogenic activity of a protein. Using microarray analysis, we identify a gene-expression subprogram regulated by...

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Source: Cancer Weekly (2008-01-15)

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