Breast Cancer

Researchers at University of California, Medical Department target breast cancer

Published in Cancer Weekly, January 15th, 2008

According to recent research from the United States, "Invasive cancer cells utilize matrix metalloproteinases (MMPs) to degrade the extracellular matrix and basement membrane in the process of metastasis. Among multiple members of the MMP family, the gelatinase MMP-2 has been implicated in the development and dissemination of malignancies."

"However, the cellular source of MMP-2 and its effect on metastatic extravasation have not been well characterized. The objective of this study was to test the hypothesis that active MMP-2 derived from endothelial cells facilitated the transmigration of breast cancer cells across the microvascular barrier. Gelatin zymography was used...

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Source: Cancer Weekly (2008-01-15)

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