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Cancer Vaccines
New cancer vaccines research has been reported by scientists at Peking University
January 15th, 2008
According to a study from Beijing, People's Republic of China, "The MAGE-A3 protein, one of the promising tumor antigens for immunotherapy, is highly expressed in human hepatocellular carcinoma (HCC). In this study, we estimated the specific CD8(+) T cell immune response to MAGE-A3 p271-279 peptide (M3(271)) in the peripheral blood of HCC patients without antigen vaccination in order to evaluate its immunotherapeutic potential in these patients." "After expansion in vitro, the functional IFN-gamma producing M3271 specific CD8(+) T cells were detected in 30.8% (8/26) of HLA-A2(+) MAGE-A3(+) HCC patients. The effector CD8+ T cells could release cytotoxic molecules of...
Source: Cancer Weekly (2008-01-15)
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