Melanoma Genetics
Study results from Leiden University, Department of Ophthalmology update understanding of melanoma genetics
Published in Cancer Weekly, January 29th, 2008
Data detailed in 'Expression of Wnt5a and its downstream effector beta-catenin in uveal melanoma' have been presented. According to a study from Leiden, Netherlands, "Upregulation of the Wnt5a pathway has been reported in some cutaneous melanomas but its role in uveal melanoma has not been assessed. We thus sought to determine whether activation of the Wnt-signalling pathway occurred in uveal melanoma through upregulation of some of the key downstream effectors, and whether expression of these components was associated with tumor characteristics and clinical outcome."
"Expression of Wnt5a, MMP7, and beta-catenin was determined in 40 primary uveal melanomas by...
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Source: Cancer Weekly (2008-01-29)
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