Squamous Cell Carcinoma
Research on squamous cell carcinoma discussed by scientists at Umea University, Department of Medical Biosciences
Published in Cancer Weekly, January 29th, 2008
Fresh data on squamous cell carcinoma are presented in the report 'DeltaNp63 isoforms regulate CD44 and keratins 4, 6, 14 and 19 in squamous cell carcinoma of head and neck.' According to a study from Umea, Sweden, "The human p63 gene codes for multiple protein isoforms and is commonly over-expressed in squamous cell carcinoma of head and neck (SCCHN). This expression is predominantly of the DeltaN-and beta-isoforms, the former lacking the p53-related transactivation domain. p63 can activate or repress transcription of p53 and p73 target genes, but also has unique transcriptional targets and, unlike other p53 family members, is required for normal development and differentiation of...
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Source: Cancer Weekly (2008-01-29)
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