Carcinoma

Scientists at Cleveland Clinic, Medical Department publish research in carcinoma

Published in Cancer Weekly, January 29th, 2008

"Recurrence of carcinomas due to cells that migrate away from the primary tumor is a major problem in cancer treatment. Immunohistochemical analyses of human carcinomas have consistently correlated up-regulation of the actin-bundling protein fascin with a clinically aggressive phenotype and poor prognosis," investigators in the United States report.

"To understand the functional and mechanistic contributions of fascin, we undertook inducible short hairpin RNA (shRNA) knockdown of fascin in human colon carcinoma cells derived from an aggressive primary tumor. Fascin-depletion led to decreased numbers of filopodia and altered morphology of cell protrusions, decreased...

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Source: Cancer Weekly (2008-01-29)

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