Fibrous Histiocytoma

Findings from C.R. Antonescu et al in fibrous histiocytoma reported

Published in Cancer Weekly, January 29th, 2008

According to recent research from the United States, "The molecular hallmark of angionnatoid fibrous histiocytoma (AFH) is not well defined, with only six cases with specific gene fusions reported to date, consisting of either FUS-ATFI or EWSRI-ATFI. To address this, we investigated the presence of FUS-ATFI, EWSRI-ATFI, and the highly related EWSRI-CREBI fusion in a group of nine AFHs."

"All cases were subjected to RT-PCR for EWSRI-ATFI and EWSRI-CREBI. FISH for EWSRI and FUS rearrangements was performed in most cases. Transcriptional profiling was performed in three tumors and their gene expression was compared to five clear cell sarcomas expressing either the...

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Source: Cancer Weekly (2008-01-29)

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