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Monoclonal Antibodies

Data from Odense University advance knowledge in monoclonal antibodies

Published in Cancer Weekly, January 29th, 2008

In this recently published article, scientists in Odense, Denmark conducted a study "To assess safety, tolerability, pharmacokinetics and clinical activity of HuMax-EGFr in patients with SCCHN. Twenty-eight patients with SCCHN were enrolled."

"The study comprised a single-dose escalation part for assessment of safety issues followed by a repeat dose extension including 4 weekly infusions at the same doses. Efficacy and metabolic response were evaluated according to RECIST by CT and FDG-PET. Most frequently reported adverse event was rash. All but one event were CTC grade 1 or 2 and a dose-dependent relationship was indicated. Duration of skin reactions varied from few...

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