Osteosarcoma

Research conducted at Third Military Medical University, Medical University Center has updated our knowledge about osteosarcoma

Published in Cancer Weekly, January 29th, 2008

According to recent research from Chongqing, People's Republic of China, "Osteosarcoma is a highly vascular and extremely destructive malignancy, and the survival of patients with osteosarcoma has not improved significantly in recent years. Antiangiogenic therapy currently holds great potential in conjunction with conventional treatment modalities for osteosarcoma."

"However, there are examples of gradual loss of response, and perhaps acquired resistance to antiangiogenic drugs. The acquired resistance of antiangiogenesis may be associated with a lot of hypoxia-response genes. The human apurinic/apyrimidinic endonuclease (Ape1) protein, a bifunctional redox factor and...

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Source: Cancer Weekly (2008-01-29)

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