Breast Cancer Therapy

Studies from University of Texas, M. D. Anderson Cancer Center add new findings in the area of breast cancer therapy

Published in Cancer Weekly, January 29th, 2008

Investigators publish new data in the report 'CtIP silencing as a novel mechanism of tamoxifen resistance in breast cancer.' According to a study from the United States, "Acquired resistance to the antiestrogen tamoxifen constitutes a major clinical challenge in breast cancer therapy. However, the mechanisms involved are still poorly understood."

"Using serial analysis of gene expression, we identified CtIP, a BRCA1-and CtBP-interacting protein, as one of the most significantly down-regulated transcripts in estrogen receptor alpha-positive (ER+) MCF-7 tamoxifen-resistant breast cancer cells. We further confirmed the association of CtIP down-regulation with tamoxifen...

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Source: Cancer Weekly (2008-01-29)

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