Cancer Genetics

Reports summarize cancer genetics study results from University of California

Published in Cancer Weekly, January 29th, 2008

Data detailed in 'Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor' have been presented. "Enhanced mesenchymal expression of FGF10 led to the formation of multifocal PIN or prostate cancer. Inhibition of epithelial FGFR1 signaling using DN FGFR1 led to reversal of the cancer phenotype," scientists in the United States report.

"A subset of the FGF10-induced carcinoma was serially transplantable. Paracrine FGF10 led to an increase in epithelial androgen receptor and synergized with cell-autonomous activated AKT. Our observations indicate that stromal FGF10 expression may facilitate...

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Source: Cancer Weekly (2008-01-29)

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