Life Sciences
New findings from Lovelace Respiratory Research Institute in the area of life sciences described
Published in Cancer Weekly, January 29th, 2008
New investigation results, 'Identification of a novel Bcl-2 promoter region that counteracts in a p53-dependent manner the inhibitory P2 region,' are detailed in a study published in Gene. "Expression of the anti-apoptotic proto-oncogene bcl-2 is negatively affected by the pro-apoptotic p53. To understand the regulation of bcl-2 expression by p53, we studied the bcl-2 promoter regions individually and in the context of the full-length promoter," scientists in the United States report.
"While the P1 promoter displayed the highest p53-independent activity, the P2 promoter activity was suppressed in p53-sufficient cancer cell lines. In addition, P2 activity was...
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Source: Cancer Weekly (2008-01-29)
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