DNA Research

Scientists at Mayo Clinic, Medical Department publish research in DNA research

Published in Cancer Weekly, February 5th, 2008

According to a study from the United States, "The glutathione S-transferases (GSTs) catalyze the glutathione conjugation of reactive electrophiles, including carcinogens and many antineoplastic drugs. GSTT1 and GSTMI are polymorphically deleted, but the full range of genetic variation in these two genes has not yet been explored."

"We set out to systematically identify common polymorphisms in GSTT1 and GSTM1, followed by functional genomic studies. First, multiplex PCR was used to determine GSTT1 and GSTM1 copy number in 400 DNA samples (100 each from 4 ethnic groups). Exons, splice junctions, and 5'-flanking regions (5'-FR) were then resequenced using DNA samples that...

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Source: Cancer Weekly (2008-02-05)

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