Life Sciences

Research from BC Cancer Research Center in the area of life sciences published

Published in Cancer Weekly, February 5th, 2008

New research, 'The effect of the fungal metabolite radicicol analog A on mRNA degradation,' is the subject of a report. According to a study from Vancouver, Canada, "The AU-rich element (ARE) is a stability determinant found in the 3' UTR of a number of short-lived mRNAs. The best characterized ARE is the Shaw-Kamen (SK) box or AUUUA motif."

"Previously, a fungal metabolite, radicicol analog A (RAA), was shown to destabilize SK box-containing mRNAs based on 16 mRNAs examined [T. Kastelic et al., Cytokine 8 (1996) 751-761]. Using serial analysis of gene expression (SAGE) to examine the global effect of RAA on mRNA expression in...

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Source: Cancer Weekly (2008-02-05)

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