Prostate Cancer

Scientists at Heinrich-Heine University, Department of Urology report research in prostate cancer

Published in Cancer Weekly, February 5th, 2008

Current study results from the report, 'Downregulation of several fibulin genes in prostate cancer,' have been published. "Fibulins, encoded by FBLN genes, are extracellular matrix proteins influencing cell adhesion and migration. Altered expression of fibulins is associated with progression of several cancer types, but has not been studied in prostate cancer," investigators in Germany report.

"Expression of FBLN1 (major splice forms C and D), FBLN4, FBLN5, SPOCK1, and TENC was compared between 47 prostate cancer samples and 13 benign prostatic tissues by quantitative RT-PCR. Fibulin-1 and fibulin-5 expression was studied by immunohistochemistry. Effects of androgens...

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Source: Cancer Weekly (2008-02-05)

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