Published in Cancer Weekly, February 12th, 2008
"Surprisingly, although FU is incorporated also into DNA, little is known about its metabolism in this nucleic acid. Using extracts of human cells and circular DNA substrates containing a single FU residue either paired with adenine or mispaired with guanine, we studied the enzymology of FU processing. In nicked circular substrates, FU/G mispairs were efficiently repaired by mismatch repair (MMR). In covalently...
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