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Non-Small Cell Lung Cancer

Researchers at University of California have published new data on non-small cell lung cancer

Published in Cancer Weekly, February 12th, 2008

According to a study from the United States, "Bortezomib and pemetrexed are approved anticancer agents with non-overlapping mechanisms of action and toxicity. We examined the safety and tolerability of pemetrexed in combination with two different schedules of bortezomib in patients with advanced solid tumors."

"Two separate dose-escalating arms (arm A and arm B) were conducted simultaneously. Patients received pemetrexed on day 1 (D1) (500-600 mg/m(2) IV) every 21 days. In arm A, bortezomib was given twice weekly (0.7-1.3 mg/m(2) on D1, 4, 8, and 11). In arm B, bortezomib was given weekly (1.0-1.6 mg/m(2) on D1 and 8). We treated 27 patients on four dose levels in arm A...

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