Prostate Cancer

Scientists at University of Kentucky target prostate cancer

Published in Cancer Weekly, February 12th, 2008

According to recent research from the United States, "Both 12-hydroxyheptadecatrienoic acid (12-HHT) and thromboxane A(2) (TXA(2)) are products derived from prostaglandin H-2 (PGH(2)) catalyzed by thromboxane synthase. Whether or not they exhibit similar actions remains to be determined."

"While TXA(2)-induced activation of extracellular signal-regulated kinases (ERKs) has been extensively studied, 12-HHT-induced activation of ERKs has not been explored. We reported for the first time that 12-HHT induced activation of ERKs in human prostate cancer cell line, PC3. We also compared the mechanisms of 12-HHT- and I-BOP-, a TXA(2) mimetic, mediated ERK activation in PC3...

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Source: Cancer Weekly (2008-02-12)

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