Life Sciences

Research in the area of life sciences reported from Korea Institute of Science and Technology

Published in Cancer Weekly, February 12th, 2008

A new study, 'Efficacy and tissue distribution of DHP107, an oral paclitaxel formulation,' is now available. "Paclitaxel is indispensable in treating human cancers. Due to poor drug solubility and efflux systems in the gastrointestinal tract, peroral delivery of paclitaxel has been a significant challenge," investigators in Seoul, Korea report.

"We developed a mucoadhesive oral formulation (DHP107) that can directly and effectively deliver paclitaxel to intestinal endothelial cells without concomitant use of P-glycoprotein inhibitors. Here, we evaluated the tissue distribution of paclitaxel, the antitumor efficacy and the absorption mechanism of DHP107. DHP107, which...

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Source: Cancer Weekly (2008-02-12)

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