Life Sciences

Researchers at Japanese Foundation for Cancer Research, Department of Experimental Pathology target life sciences

Published in Cancer Weekly, February 12th, 2008

New research, 'The complete removal of cohesin from chromosome arms depends on separase,' is the subject of a report. According to recent research published in the Journal of Cell Science, "Cohesin needs to be removed from chromosomes to allow sister chromatid separation in mitosis. In vertebrates, two pathways contribute to this process."

"The prophase pathway, which requires phosphorylation of the cohesin subunit SA2 and a cohesin-binding protein, called Wapl, removes the bulk of cohesin from the chromosome arms in early mitosis and allows the resolution of the chromosome arms. At anaphase onset, the protease separase removes centromere-enriched cohesin by...

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Source: Cancer Weekly (2008-02-12)

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