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Scientists at Utrecht University, Utrecht Institute for Pharmaceutical Science publish research in life sciences

Published in Cancer Weekly, February 12th, 2008

Scientists discuss in 'Targeted analysis of protein termini' new findings in life sciences. "We describe a targeted analysis of protein isoforms by selective enrichment and identification of in vivo acetylated protein N-termini and protein C-termini. Our method allows the characterization of these protein termini regardless of their annotation in protein databases and requires no chemical derivatization," scientists in Netherlands report.

"Using an iterative database search strategy that takes account of the enrichment protocol, 263 IPI annotated and 87 unpredicted acetylated N-termini were identified in the crude membrane fraction of human embryonic carcinoma cells....

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