Phosphatase
Findings from European Institute of Oncology, Department of Experimental Oncology provide new insights into phosphatase
Published in Cancer Weekly, February 12th, 2008
A report, 'APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus,' is newly published data in Genes & Development. According to a study from Milano, Italy, "In the budding yeast Saccharomyces cerevisiae, the protein phosphatase Cdc14 triggers exit from mitosis by promoting the inactivation of cyclin-dependent kinases (CDKs). Cdc14's activity is controlled by Cfi1/Net1, which holds and inhibits the phosphatase in the nucleolus from G1 until metaphase."
"During anaphase, two regulatory networks, the Cdc14 Early Anaphase Release (FEAR) network and the Mitotic Exit Network (MEN), promote the dissociation of...
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Source: Cancer Weekly (2008-02-12)
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