Published in Cancer Weekly, February 19th, 2008
"Parathyroid hormone-related protein (PTHrP) and macrophage inflammatory protein-lot (MIP-1 alpha) are important factors in the pathogenesis of HHM in ATLL and the expression of PTHrP can be activated by nuclear factor kappa B (NF-kappa B). NF-kappa B is constitutively activated in ATLL cells and is essential for leukemogenesis including transformation of lymphocytes infected by...
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