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John Wayne Cancer Institute Researchers Show that a Key Protein Appears to Enable Spread of Melanoma to the Small Intestine

Published in Cancer Weekly, February 19th, 2008

A study by researchers at the John Wayne Cancer Institute at Saint John's Health Center has shown that a receptor protein found on melanoma cells appears to facilitate the disease's spread to the small intestine.

The study, published in the Feb. 1, 2008, issue of Clinical Cancer Research, also suggests that merging of the protein, called CCR9, with the CCL25 protein, which is known to play a role in the development of disease-fighting white blood cells, may help to explain the high incidence of melanoma metastasis to the lower bowel.

Melanoma is the most serious type of skin cancer, with more than 53,000 people in the U.S. diagnosed each year. Over...

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