Ovarian Cancer

Research from St. James University yields new findings on ovarian cancer

Published in Cancer Weekly, February 26th, 2008

Researchers in Leeds, the United Kingdom conducted a study "To discover and validate serum glycoprotein biomarkers in ovarian cancer using proteomic-based approaches. Serum samples from a ''discovery set''of 20 patients with ovarian cancer or benign ovarian cysts or healthy volunteers were compared by fluorescence two-dimensional differential in-gel electrophoresis and parallel lectin-based two-dimensional profiling."

"Validation of a candidate biomarker was carried out with Western blotting and immunoassay (n = 424). Twenty-six proteins that changed significantly were identified by mass spectrometric sequencing. One of these, confirmed by Western blotting, was afamin,...

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Source: Cancer Weekly (2008-02-26)

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