Apoptosis

Pharmacyclics Announces Data and Publication Characterizing Highly-Selective HDAC Inhibitor

Published in Cancer Weekly, February 26th, 2008

Pharmacyclics, Inc. (NASDAQ:PCYC) announced publication of data characterizing the company's novel highly-selective histone deacetylase (HDAC) inhibitor. The study, entitled "A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas," appears in the February 7 issue of Leukemia.

Histone deacetylases are a family of related enzymes important in managing a multitude of cellular functions. HDAC inhibitors are a new class of drugs that modulate transcriptional activity in cells and may block angiogenesis and cell cycling, key components of tumor proliferation. HDAC inhibitors also appear to promote apoptosis (cell death) in...

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Source: Cancer Weekly (2008-02-26)

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