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Cancer Gene Therapy
Data from Nagoya University, Department of Biochemistry provide new insights into cancer gene therapy
March 11th, 2008
New research, 'In vivo silencing of a molecular target by short interfering RNA electroporation: tumor vascularization correlates to delivery efficiency,' is the subject of a report. "Screening for a molecular target for cancer therapy requires multiple steps, of which an important one is evaluation of the knockdown effect of the target molecule on pregrown xenograft tumors. However, methods currently used for local administration of knockdown reagents, such as short interfering RNA (siRNA), are not satisfactory as to simplicity and efficiency," investigators in Nagoya, Japan report. "We established an electroporation method involving a constant voltage and 'plate and...
Source: Cancer Weekly (2008-03-11)
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