Cancer Weekly
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Adenocarcinoma
Scientists at University of California target adenocarcinoma
March 11th, 2008
According to recent research published in the journal Applied Immunohistochemistry & Molecular Morphology, "CD44 is an 85 to 90kd integral transmembrane protein encoded by a single 20-exon gene located on the short arm of chromosome 11. In the standard form (CD44s), 10 of the 20 exons are transcribed." "Multiple variant isoforms exist (CD44v1-10) which arise from alternate mRNA splicing of the remaining 10 exons. In contrast to the standard form of CD44, which is almost ubiquitously expressed, splice variants are highly restricted in their expression in normal or malignant tissues. The purpose of this study was to evaluate the extent to which metastatic...
Source: Cancer Weekly (2008-03-11)
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