Cancer Weekly
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Adenovirus
New adenovirus study findings have been reported by A. Facciabene and colleagues
March 11th, 2008
According to a study from Pomezia, Italy, "Vectors encoding CEA fused to the A (CEA-LTA) or B (CEA-LTB) subunits of the heat-labile enterotoxin were constructed and their immunogenicity was compared. The CEA-LTB fusion was shown to elicit a greater CEA-specific antibody and CD8(+) T-cell response." "Plasmid DNA and Adenovirus vectors encoding CEA-LTB proved to be immunogenic in CEA transgenic (CEA.tg) mice. CEA.tg mice immunized with repeated injections of plasmid pV1J/CEA-LTB followed by Ad/CEA-LTB were protected from tumor growth, but the adjuvant activity of the LTB protein was Lost upon mutation of the LTB sequence. Depletion of T-regulatory cells increased the...
Source: Cancer Weekly (2008-03-11)
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