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Apoptosis
Research from University of Washington broadens understanding of apoptosis
March 11th, 2008
"The MYConcogene induces both cell proliferation and apoptosis. The apoptotic function of MYC is thought to inhibit carcinogenesis; thus, when disrupted, tumorigenic potential is increased," scientists in the United States report. "Both MYC and transforming growth factor alpha (TGF alpha) are commonly over-expressed in hepatocellular carcinomas, and transgenic mice expressing these genes rapidly develop tumors via the suppression of MYC-induced apoptosis by the growth factor. However, the nature of the interactions between MYC and TGF alpha are not well understood. Specifically, it is unclear whether TGF alpha acts only as an anti-apoptotic factor in its interactions...
Source: Cancer Weekly (2008-03-11)
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