Cancer Weekly
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Astrocytoma
New astrocytoma research from A. Misra et al outlined
March 11th, 2008
"A verifiable consequence of the mutator hypothesis is that even low grade neoplasms would accumulate a large number of mutations that do not influence the tumor phenotype (clonal mutations). In this study, we have attempted to quantify the number of clonal mutations in primary human gliomas of astrocytic cell origin," scientists in New Delhi, India report. "These alterations were identified in tumor tissue, microscopically confirmed to have over 70% neoplastic cells. Random Amplified Polymorphic DNA (RAPD) analysis was performed using a set of fifteen 10-mer primers of arbitrary but definite sequences in 17 WHO grade II astrocytomas ( low grade diffuse astrocytoma or...
Source: Cancer Weekly (2008-03-11)
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