Cancer Weekly
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Astrocytoma
Research from University of Patras, Medical Department in the area of astrocytoma published
March 11th, 2008
"Neurotrophins are growth factors that regulate cell growth, differentiation and apoptosis in the nervous system. Their diverse actions are mediated through two different transmembrane - receptor signaling systems: Trk receptor tyrosine kinases ( TrkA, TrkB, TrkC) and p75NTR neurotrophin receptor," scientists in Patras, Greece report. "Trk receptors promote cell survival and differentiation while p75NTR induces, in most cases, the activity of JNK-p53-Bax apoptosis pathway or suppresses intracellular survival signaling cascades. Robust Trk activation blocks p75NTR - induced apoptosis by suppressing the JNK-p53-Bax pathway. The aim of this exploratory study was to...
Source: Cancer Weekly (2008-03-11)
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