Pancreatic Cancer

Researchers at Ohio State University, Division of Pharmaceutics have published new data on pancreatic cancer

Published in Cancer Weekly, March 11th, 2008

Researchers detail in 'A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells,' new data in pancreatic cancer. "Pancreatic cancer is an aggressive disease with multiple biochemical and genetic alterations. Thus, a single agent to hit one molecular target may not be sufficient to treat this disease," scientists in the United States report.

"The purpose of this study is to identify a novel Hsp90 inhibitor to disrupt protein-protein interactions of Hsp90 and its cochaperones for down-regulating many oncogenes simultaneously against pancreatic cancer cells. Here, we reported that celastrol disrupted Hsp90-Cdc37 interaction in the...

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Source: Cancer Weekly (2008-03-11)

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