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BMC Cancer
Findings from S. Sheahan and co-authors provide new insights into BMC cancer
March 11th, 2008
According to recent research from Scotland, "TGF beta is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity. The retinoblastoma protein pRb is a key controller of E2F activity and G1/S transition which can be inhibited in viral hepatitis." "It is not known whether the impairment of pRb would alter the growth inhibitory potential of TGF beta in disease. We asked how Rb-deficiency would affect responses to TGF beta-induced cell cycle arrest. Primary hepatocytes isolated from Rb-floxed mice were infected with an adenovirus expressing CRE-recombinase to delete the Rb gene....
Source: Cancer Weekly (2008-03-11)
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