Cancer Weekly
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Breast Cancer
Studies conducted at National University on breast cancer recently published
March 11th, 2008
"To identify novel tyrosine kinase substrates that have never been implicated in cancer, we studied the phosphoproteomic changes in the MCF10AT model of breast cancer progression using a combination of phosphotyrosyl affinity enrichment, iTRAQ (TM) technology, and LC-MS/MS. Using complementary MALDI- and ESI-based mass spectrometry, 57 unique proteins comprising tyrosine kinases, phosphatases, and other signaling proteins were detected to undergo differential phosphorylation during disease progression," scientists writing in the journal Molecular & Cellular Proteomics report. "Seven of these proteins (SPAG9, Toll-interacting protein (TOLLIP), WBP2, NSFL1C,...
Source: Cancer Weekly (2008-03-11)
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