Cancer Weekly
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Cancer Gene Therapy
New cancer gene therapy findings from Gene Therapy Center described
March 11th, 2008
According to recent research from Shanghai, People's Republic of China, "Hepatocellular carcinoma (HCC) is the most invasive and frequently diagnosed malignancy and the second leading cause of cancer death in many regions of Asia. The PI3K/Akt/mTOR signal pathway is involved in multiple cellular functions including proliferation, differentiation, tumorigenesis, and apoptosis." "Up-regulation of telomerase activity is thought to be a critical step leading to cell transformation. This study investigated changes in mTOR pathway and telomerase activity in hepatocarcinoma cell line SMMC-7721 treated with chemotherapeutic agent 5-fluorouracil (5-Fu). We detected apoptosis of...
Source: Cancer Weekly (2008-03-11)
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