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Gene Therapy
Data on gene therapy published by researchers at University of Munich
March 18th, 2008
According to recent research published in the journal Gene Therapy, "A novel class of cationic hyperbranched polymers, containing branched oligoethylenimine ( OEI 800 Da) as core, diacrylate esters as linkers and oligoamines as surface modification, was synthesized and evaluated regarding their structure activity relationship as gene carriers. We show that pseudodendritic core characteristics as well as different surface modifications on the core influence DNA-binding ability, cytotoxicity and transfection efficiency." "As most promising gene carrier, the pseudodendrimer HD O, that is, the OEI 800 Da core modified with hexane-1,6-diol diacrylate and...
Source: Cancer Weekly (2008-03-18)
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