Cancer Weekly
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Gene Therapy
Studies from A. Quintascardama et al add new findings in the area of gene therapy
March 18th, 2008
According to recent research from the United States, "The ability to genetically modify human T cells to target tumor antigens through retroviral gene transfer constitutes a potentially powerful approach to cancer immunotherapy. However, low transduction efficiencies may hamper the efficacy of such therapeutic strategies in the clinical setting." "Most commonly, gammaretroviral gene transfer into T cells is conducted through spinoculation, that is, centrifugation of retroviral particles and T cells on RetroNectin-coated non-tissue culture vessels. Here we present data investigating the impact of temperature, speed, and frequency of spinoculation on T cell transduction...
Source: Cancer Weekly (2008-03-18)
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