Cancer Weekly
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Cancer Gene Therapy
Research conducted at National Institutes of Health has provided new information about cancer gene therapy
March 18th, 2008
Data detailed in 'The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers' have been presented. According to recent research published in the Journal of Clinical Investigation, "The aryl hydrocarbon receptor repressor (AHRR) is a bHLH/Per-ARNT-Sim transcription factor located in a region of chromosome 5 (5p15.3) that has been proposed to contain one or more tumor suppressor genes. We report here consistent downregulation of AHRR mRNA in human malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary, and demonstrate DNA hypermethylation as the regulatory mechanism of AHRR gene...
Source: Cancer Weekly (2008-03-18)
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