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Cancer Gene Therapy
Research from McGill University, Department of Medicine in the area of cancer gene therapy published
March 18th, 2008
Fresh data on cancer gene therapy are presented in the report 'Transforming growth factor-beta inhibits telomerase through SMAD3 and E2F transcription factors.' "Cancer arises from multiple genetic changes within the cell, among which constitutive telomerase activity and attainment of immortality are central. Expression of hTERT, the protein component of telomerase, is increased in most cancer cells," scientists writing in the journal Cellular Signalling report. "Transforming growth factor-beta (TGFbeta), a potent tumor suppressor, has been reported to regulate hTERT expression. We found that TGFbeta represses hTERT expression in normal and cancer cells and that...
Source: Cancer Weekly (2008-03-18)
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