Cancer Weekly
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Enzyme Research
Studies from Ohio State University, Department of Biochemistry describe new findings in enzyme research
March 18th, 2008
A report, 'Characterization of a bacterial beta-1,3-galactosyltransferase with application in the synthesis of tumor-associated T-antigen mimics,' is newly published data in Biochemistry. "T-Antigen (Gal-beta1,3-GalNAc-alpha-O-Ser/Thr) is an important precursor of mucin-type O-glycans. T-Antigen is found to be closely associated with cancer progression and metastasis and has been used to develop carbohydrate-based anticancer vaccines," investigators in the United States report. "Enzymatic synthesis of T-antigen disaccharides have relied on the use of beta-1,3-galactosyltransferases recently cloned and characterized from several eukaryotic organisms. However, its...
Source: Cancer Weekly (2008-03-18)
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