Molecular Imaging
Recent studies from University of Milan add new data to molecular imaging
Published in Cancer Weekly, March 18th, 2008
" The aim of this study was to develop a cellular model for the concurrent imaging of reporter genes expression by using positron emission tomography (PET) and bioluminescence imaging (BLI) for the assessment of estrogen receptor activity in vivo in a breast cancer model. Two reporters were chosen: a mutated form of the dopaminergic D2 receptor (D(2)R80A) for PET imaging, and the Firefly Luciferase for BLI," scientists in Milan, Italy report.
"The presence of an IRES sequence between the two reporters ensured the coordinated expression driven by the same regulatory sequence containing an estrogen responsive element (ERE). To prevent chromatin effects on reporter...
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Source: Cancer Weekly (2008-03-18)
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