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Cancer Weekly

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Life Sciences



New life sciences findings from National Institute of Environmental Health Sciences described



March 18th, 2008

New investigation results, 'Intersection of nuclear receptors and the proteasome on the epigenetic landscape,' are detailed in a study published in Environmental and Molecular Mutagenesis. "Nuclear receptors (NRs) represent a class of transcription factors that associate with both positive and negative chromatin modifying complexes to activate or repress gene transcription. The 26S proteasome plays a major role in NR-regulated gene transcription by tightly regulating the levels of the receptor and coregulator complexes," scientists in the United States report.

"Recent evidence suggests a robust nonproteolytic role for specific proteasome subunits in gene...


Source: Cancer Weekly (2008-03-18)

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