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Cancer Gene Therapy
Research from X.B. Qian and colleagues has provided new data on cancer gene therapy
March 18th, 2008
"Human telomerase reverse transcriptase (hTERT) is an attractive target for cancer gene therapy. However, the poor inhibition of telomerase and a time lag between the inhibition and arrest of cell proliferation limits its use in cancer gene therapy," scientists in Nanjing, People's Republic of China report. "RNA interference (RNAi) has been proposed as a potential technique for the treatment of cancer with a long-term gene silencing response induced by short hairpin RNA (shRNA). To investigate the long-term effects of telomerase inhibition through the down-regulation of the hTERT gene and the potential role of hTERT in cancer gene therapy, we constructed an...
Source: Cancer Weekly (2008-03-18)
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