Cancer Weekly
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RNA Research
Studies from U. Stein and co-researchers in the area of RNA research published
March 25th, 2008
"Triggering the RNA interference (RNAi) pathway by inducing the expression of short hairpin RNA (shRNA) molecules has become a promising tool for efficient silencing of a given gene in gene therapy applications. In this study, shRNA encoding DNA was utilized to reverse the classical MDR1/P-glycoprotein (MDR1/Pgp)mediated multidrug resistance (MDR) phenotype in vivo," scientists in Berlin, Germany report. "For the first time, the nonviral jet-injection technology was applied for delivering naked shRNA-vector constructs for direct intratumoral in vivo transfer. The highly efficient anti-MDR1 shRNA expression vectors were applied twice in the human MDR1/P-gp...
Source: Cancer Weekly (2008-03-25)
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