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Cancer Gene Therapy
Research results from R. Malaguarnera and colleagues update understanding of cancer gene therapy
March 25th, 2008
A new study, 'TAp73 alpha increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation,' is now available. According to recent research from Italy, "p53 family proteins include p53 tumor suppressor, p63, and p73. Despite the high similarity in structure and function with p53, p63, and p73 function in tumor suppression is still controversial." "Here, we show that TAp73alpha, a transcriptionally active p73 isoform, is able to synergize p53 tumor suppressor function in thyroid cancer cells. Indeed, depletion of p73 by small interfering RNA in thyroid cancer cells resulted in a reduced transcriptional activity of p53....
Source: Cancer Weekly (2008-03-25)
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