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Ataxia Telangiectasia
Findings from M.L. Cortes and co-researchers advance knowledge in ataxia telangiectasia
March 25th, 2008
"Ataxia-telangiectasia (A-T) is an autosomal recessive disorder characterized by neurodegeneration, immunodeficiency, cancer predisposition, genome instability, and sensitivity to ionizing radiation (IR). We have previously shown that a herpes simplex virus type 1 (HSV-1) amplicon vector carrying the human ataxia-telangiectasia mutated (ATM) complementary DNA (cDNA) is able to correct aspects of the cellular phenotype of human A-T cells in culture, and is also able to transfer the ATM cDNA to the Atm(-/-) mouse cerebellum," researchers in the United States report. "In order to achieve stable gene replacement, we have generated an HSV/adeno-associated virus (AAV) hybrid...
Source: Cancer Weekly (2008-03-25)
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