Cancer Weekly
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Gene Therapy
Recent findings in gene therapy described by N. Chetoui and colleagues
March 25th, 2008
Investigators publish new data in the report 'Down-regulation of mcl-1 by small interfering RNA sensitizes resistant melanoma cells to fas-mediated apoptosis.' "Resistance of malignant melanoma cells to Fas-mediated apoptosis is among the mechanisms by which they escape immune surveillance. However, the mechanisms contributing to their resistance are not completely understood, and it is still unclear whether antiapoptotic Bcl-2-related family proteins play a role in this resistance," scientists in Sainte-Foy, Canada report. "In this study, we report that treatment of Fas-resistant melanoma cell lines with cycloheximide, a general inhibitor of de novo protein synthesis,...
Source: Cancer Weekly (2008-03-25)
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