Cancer Gene Therapy

New cancer gene therapy research has been reported by scientists at Oita University, Medical Department

Published in Cancer Weekly, March 25th, 2008

According to recent research from Oita, Japan, "The purpose of this study was to analyze loss of p16 expression and its relationship to hypermethylation, clinicopathological parameters and prognosis in patients with esophageal squamous cell carcinoma (ESCC). Tissue samples from 60 ESCC were subjected to histological analysis."

"Immunohistochemical staining for p16 expression was performed. DNA was extracted from these primary esophageal tumors and from sera from another 38 ESCC patients. The DNA was modified with bisulfite and analyzed for p16 promoter methylation by methylation-specific polymerase chain reaction. Twelve out of the 60 tumors (20%) were methylated at the...

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Source: Cancer Weekly (2008-03-25)

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