Cancer Weekly
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Angiogenesis
Reports on angiogenesis findings from University of Toronto provide new insights
March 25th, 2008
"MicroRNAs are single-stranded RNA of 18-24 nt expressed enclogenously that play important roles in cancer development. Here, we show that expression of miR-378 enhances cell survival, reduces caspase-3 activity, and promotes tumor growth and angiogenesis," scientists in Toronto, Canada report. "Proteomic analysis indicates reduced expression of suppressor of fused (Sufu), a potential target of miR-378, which was confirmed in vitro and in vivo. Expression of a luciferase construct containing the target site in Sufu was repressed when cotransfected with miR-378. Transfection of a Sufu construct reversed the effect of miR-378, suggesting an important role for miR-378 in...
Source: Cancer Weekly (2008-03-25)
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